how do you do是相对比较正式的问候，常见于60、70年代，现代人见面很少说这句话了。回答有I 'm fine，I 'm good 。

1、中规中矩的回复：如果有人问你How do you do？你也可以同样问那人how do you do ?

2、可以用how are you？的回答来应对。举例：

I’m fine, and how are you?

Pretty good, and how do you do?

3、以直接回答Nice to meet you.可以说是非常灵活的。

1、How are you?你好吗？

how are you 英[hau ɑ: ju:] 美[haʊ e(r) ju]

例句：How are you?

翻译：你身体好不？

2、How are you doing?你好吗？

例句：Hi! How are you doing?

翻译：嗨！你近来怎么样？

3、How is your day? 今天过得如何？

例句：How is your day?

翻译：你今天过得如何？

4、How is everything going these days?这些日子过得怎么样？

例句：Dear Robert: How is everything going with you these days?

翻译：Jean亲爱的罗伯特：你这些天过得怎么样啊？